Watch Closely (two)pentobarbital will lessen the extent or effect of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Robust CYP3A4 inducers might minimize suvorexant efficacy; if improved suvorexant dose required, never exceed 20 mg/working daypentobarbital will reduce the level or effect of diltiaz